Double-sided tape for tissues could replace surgical sutures

Inspired by a gluey substance that spiders used to catch their victim, MIT engineers have designed a double-sided tape that may rapidly secure tissues together.

In tests in rats and pig tissues, the scientists indicated that their new tape can securely bind cells like the lungs and intestines within just five moments. They hope that this tape could eventually be used rather than surgical sutures, which don’t work nicely in every cells and certainly will trigger problems in certain patients.

“There tend to be over 230 million significant surgeries all over the world annually, and several of those need sutures to close the injury, which could actually cause pressure on the tissues and can trigger infections, discomfort, and scars. We have been proposing a basically various way of sealing structure,” claims Xuanhe Zhao, an associate at work teacher of technical manufacturing and of municipal and environmental manufacturing at MIT and the senior composer of the study.

The double-sided tape could also be used to attach implantable health devices to areas, including the heart, the researchers showed. Besides, it works even more quickly than muscle glues, which generally just take a few minutes to bind firmly and will trickle onto the rest regarding the body.

Graduate students Hyunwoo Yuk and Claudia Varela will be the lead writers of this research, which appears these days in Nature. Other authors are MIT graduate student Xinyu Mao, MIT associate professor of technical engineering Ellen Roche, Mayo Clinic important treatment doctor Christoph Nabzdyk, and Brigham and Women’s Hospital pathologist Robert Padera.

a strong seal

Forming a good seal between cells is recognized as become extremely tough because liquid on top of this cells inhibits adhesion. Current tissue adhesives diffuse adhesive molecules through liquid between two tissue areas to bind all of them together, but this process may take several minutes and even much longer.

The MIT team wanted to produce a thing that would work much faster. Zhao’s group had formerly created various other novel adhesives, including a hydrogel superglue providing you with harder adhesion compared to the sticky products that take place in nature, such as those that mussels and barnacles used to cling to ships and rocks.

To produce a double-sided tape which could quickly join two wet surfaces together, the group drew inspiration from the normal world — especially, the gluey product that spiders use to capture their particular prey in damp circumstances. This spider glue includes recharged polysaccharides that can soak up liquid from surface of a pest easily, clearing down a little dried out spot your glue can adhere to.

To mimic this by having an designed adhesive, the researchers created a material that very first digests water from damp areas after which rapidly binds two areas together. For liquid absorption, they utilized polyacrylic acid, a very absorbent material which is used in diapers. Once the tape is used, it sucks up liquid, allowing the polyacrylic acid to quickly form weak hydrogen bonds with both cells.

These hydrogen bonds alongside poor interactions temporarily contain the tape and areas set up while substance groups labeled as NHS esters, that your scientists embedded inside polyacrylic acid, kind stronger bonds, known as covalent bonds, with proteins inside tissue. This takes about five moments.

To produce their particular tape tough enough to last in the body, the researchers included either gelatin or chitosan (a tough polysaccharide found in insect shells). These polymers enable the glue to carry its form for long durations. With regards to the application that the tape is being employed for, the researchers can control how quickly it breaks down in the human body by varying the ingredients that get into it. Gelatin will break down in a few days or days in the human body, while chitosan will last longer (four weeks or up to a 12 months).

“Combining two revolutionary concepts, the research group succeeded in adhering quickly and effortlessly towards the wet and smooth area of a structure, and in maintaining great adhesion and technical properties for a couple of days without causing excessively inflammatory response,” states Costantino Creton, an investigation director at ESPCI Paris, who was perhaps not active in the research.

Rapid recovery

This type of adhesive might have a significant effect on surgeons’ capacity to seal cuts and heal injuries, Yuk says. To explore feasible applications when it comes to new double-sided tape, the scientists tested it in some several types of pig structure, including epidermis, tiny bowel, belly, and liver. In addition they performed tests in pig lung area and trachea, showing that they could quickly fix harm to those body organs.

“It’s extremely difficult to suture smooth or delicate areas for instance the lung and trachea, but with our double-sided tape, within five seconds we are able to quickly secure all of them,” Yuk says.

The tape in addition worked really to seal problems for the gastrointestinal area, that could be invaluable in avoiding leakage that occasionally happens following surgery. This leakage could cause sepsis as well as other potentially deadly complications.

“I anticipate great translational potential with this elegant approach into numerous medical practices, and basic manufacturing applications, in particular in situations in which medical operations, particularly suturing, aren’t simple,” states Yu Shrike Zhang, an assistant professor of medicine at Harvard healthcare class, who was simply maybe not involved in the study.

Implanting medical devices within the body is yet another application the MIT group is exploring. Working together with Roche’s lab, the scientists showed that the tape might be used to solidly connect a small polyurethane area towards the minds of residing rats, that are concerning the measurements of a thumbnail. Ordinarily this type of treatment is extremely difficult and needs a professional physician to perform, nevertheless study group managed to just stick the plot on making use of their tape by pushing for some moments, and it also stayed set up for several days.

Aside from the polyurethane heart area, the scientists found that the tape could effectively attach materials like silicone rubberized, titanium, and hydrogels to cells.

“This supplies a more elegant, more simple, plus universally relevant way of exposing an implantable monitor or medicine distribution device, because we could abide by numerous web sites without causing damage or secondary problems from puncturing structure to affix the devices,” Yuk claims.

The researchers are actually using the services of medical practioners to spot extra programs with this type of adhesive and to perform more tests in animal designs.

The investigation was financed because of the National Science Foundation in addition to workplace of Naval Research. Commercialization of tasks are being supported by the MIT Deshpande Center for Technological Innovation.